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8 Many molecular markers have been speculated to affect outcome, and examples are microsatellite instability (MSI-H), tumor-DNA ploidy, chromosomal deletions, and mutated p53.
The variable regions have previously been identified as the exposed loops between membrane-embedded β sheets, and the observed diversity has been speculated to affect the interaction of ChuA with the siderophore or to result from the selective pressure by the host immune system (Hofreuter et al. 2006).
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Such variants are speculated to affect the rate or the extent of RCL insertion into the A-sheet.
Among the other novel TH target genes selected for further analysis, LMO2 is a member of a family of genes encoding Lim-only proteins, which are speculated to affect the development of the mouse CNS because of their high expression in this region [53] [55].
As for function, this polymorphism was speculated to affect mRNA [ 39].
Given that SUCNR1 was speculated to affect lipolysis [ 22], we sought to determine if systemic levels of free fatty acids (FFA) and glycerol varied in our paradigm and could account for increased outer retinal lipid deposition.
Msi proteins have been proposed to act as translational repressors of mRNAs and sometimes as activators (MacNicol et al., 2011)—when bound to mRNA 3′ UTRs, and were speculated to affect pre-mRNA processing in Drosophila (Nakamura et al., 1994; Okano et al., 2002).
Although the available evidence is not sufficiently strong, microbiome types are speculated to eventually affect a person's risk of disease or response to distinct drugs [ 9].
Repetitive sequences are speculated to influence cytoplasmic, cellular and developmental processes [86] by increasing genome size and affecting chromosomal recombination.
It has been speculated that PCBs may affect brain development by interfering with thyroid hormone (TH) signaling.
Because an enhanced tea effect on FMD was found with the proximal cuff placement, it may be speculated that tea affects the vasodilatory response beyond affecting NO bioavailability via mechanisms still to be revealed [58], [62].
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