From these observations, it can be speculated that reducing postprandial glucose fluctuations in obese women could reduce rates of preeclampsia and/or LGA infants.
It has been speculated that the reduced bone formation using local treatment is caused by unbound bisphosphonate being released, reaching high tissue concentrations also in vivo.
Because of their effects in improving surrogate markers, it had been speculated that agents that reduce insulin resistance might have better outcomes than agents that provide insulin.
Furthermore, it has been speculated that if fats are reduced from the diet, it may become high in sucrose.
It has been speculated that drug efficacy is reduced by the continuous overexpression of the drug target, a phenomenon that may be mediated by the down-regulation of miR-125 and miR-331 (Kovalchuk et al. 2008) whose normal function is to suppress HER2.
It has been speculated that stable prostacyclin analogues reduce lung and lymph node metastasis in mammary carcinoma models [ 114].
Given their anti-inflammatory roles in the reduction of COX activity and prostaglandin synthesis, therefore [ 37, 42], it has been speculated that treatment with NSAIDs might reduce the risk of prostate cancer [ 43].
It has been speculated that phage-encoded MazG operates to reduce the ppGpp pool within stationary-phase infected cells [ 52], thus enhancing propagation of phage progeny in bacterial cells growing in nutrient limiting conditions.
It has been speculated that extended bronchodilation from tiotropium might reduce infection rates by improving clearance of respiratory secretions, such as sputum production during exacerbations, which in turn improves lung defence mechanisms [ 46].
Since LIPH encodes PA-PLA1α with a pla1 activity expressed in the skin, it has been speculated that loss-of-function of LIPH would reduce the production of LPA in hair follicles that could affect the migration, differentiation, or proliferation of keratinocytes, culminating in the arrest of hair growth [13].
