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It has also been speculated that modulation of the cytokine environment by anti-TNF therapy is related to the formation of granulomas.
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Studies of moths have shown that the responses of neurons in the male antennal lobe (the primary olfactory center in insects) to female sex pheromone are enhanced by serotonin [ 42], and it has been speculated that modulations of mate-seeking behavior as a function of circadian cycle [ 43] and satiation of the mating drive [ 44] may occur through such neuromodulatory mechanisms [ 43].
So, it can be speculated that modulation of IFN signature as mediated by common miRs in replicon cells, can mirror de-regulation of the IFN signaling proposed for such patients.
It has been speculated that pharmacologic modulation of Notch signaling could be a promising new target for the treatment of skin cancer.
In relation to the latter connection, it has been speculated that unintended modulation of cytoplasmic Src-family tyrosine kinases by certain inhibitors of protein kinases might be responsible for drug-induced lupus erythematosus [ 64].
It has been speculated that effects may be frequency or modulation dependent [ 36] and, in such a case, estimating average exposure would not be the most appropriate exposure metric.
It has been speculated that potentially beneficial effects could be due to olive oil modulation on genes involved in proliferative, antioxidant and inflammatory pathways.
It has been speculated that the potential beneficial effects of olive oil could be due to modulation of genes involved in proliferative, antioxidant and inflammatory pathways.
Therefore, it has been speculated that the mechanism by which proteasome inhibitors may induce TMA also involve modulation of VEGF.
It has been speculated that scar formation leads to tape shortening and stiffening.
Initially, it was speculated that the mechanism behind TLR modulation may be via inhibition of NFκB (Gomariz et al. 2005).
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