Therefore, it is speculated that expression of Δ256Foxo1 inhibits endogenous Foxo1 in AGRP neurons and rescues phenotypes of AGRPPdk1−/− mice.
Therefore, it is speculated that expression of the bukII is only efficiently activated when fermenting some non-preferable sugars (such as d-xylose and l-arabinose) because, compared to d-glucose metabolism, a higher ATP demand is required then [ 74].
It is speculated that expression of the thlA gene is constitutive [ 35] and recent experiments indicate that the difference in transcription levels of thlA between acidogenesis and solventogenesis is much less marked than that of ctfA/B, adc, and adhE [ 36].
It has been speculated that increased expression of CYP24A1 due to gene amplification may abrogate vitamin D3-mediated growth control.
Underlying mechanisms are unknown, but it has been speculated that reduced CD28 expression may go hand in hand with less active aerobic glycolysis.
It has been speculated that STAT3 36 regulates expression of MYC (Fig. 1), which may have potentiated apoptosis in the present study.
It has been speculated that tissue-specific expression of RBP4 is linked to the binding of retinol from plasma in the immediate vicinity of, and for specific use by, its tissue of origin [ 49, 50].
In the context of MMP function related to tumour progression, it has been speculated that enhanced MMP expression facilitates tumour cell invasion and metastasis, ultimately resulting in poor prognosis.
It has been speculated that persistent nuclear expression of Nrf2 in gastric cancer cell lines results in the production of antioxidants, which confer on these cancer cell lines a high ability to resist reactive oxygen species (ROS).
Combined with previously reported lower nitrite levels with 1,25(OH)2D, it has been speculated that this increased p53 expression may favor DNA repair over apoptosis.
