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It has been speculated that excessive or abnormal forces within the MTPJ, provoked by severe overextension of the joint in combination with hindlimb rotation in particular, will heavily load the plantar supporting structures, especially the PSBs and the ISL [ 2].
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It can thus be speculated that excessive hepcidin leads to an increase in iron storage and reduces the amount of serum iron available for Hb synthesis and erythrocyte production, which leads in turn to anemia in RA.
It is speculated that excessive stress, fatigue, and close contact with HFMD patients might contribute to this disease in adults, but the pathogenic mechanism of adult HFMD remains to be well elucidated.
It is speculated that this formulation generates excessive amounts of unbound pDNA in the solution that can inhibit the available bound pDNA from cellular entry and release.
It might be speculated that mainly the reduction in excessive pulmonary flow per se achieves the reduction in PAP in these cases.
Therefore, it was speculated that YAP overexpression might be sufficient to drive excessive skeletal muscle formation.
However, considering that avian influenza causes an excessive immune response, it could be speculated that appropriately regulated immunity does not hamper the body's normal resistance to AIV.
We're speculating that nothing will happen.
The prolonged hyperglycaemia that results in diabetic patients has been speculated to induce oxidative stress through the excessive generation of free radicals which may impair endogenous antioxidant defence [ 8].
There was no evidence, however, that King Tut suffered from Marfan syndrome or gynecomastia (a hormonal imbalance that manifests as excessive breast-development in men), as had been speculated.
While this implicates the tight regulation of NCAM heterophilic interactions as a prerequisite for normal embryonic development, it is tempting to speculate that excessive stimulation of FGFR by soluble NCAM contributes to the phenotype of mutant mice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com