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While it has been speculated that DNA methylation defects cause this disease, little is known about the molecular function of CDCA7 and its functional relationship to HELLS and DNMT3b.
It has long been speculated that DNA methylation in neurons might be involved in memory encoding (Holliday 1999).
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Therefore, it has been speculated that maintenance of DNA methylation by DNA methyltransferase 1 (DNMT1) is incomplete resulting in a gradual decrease of DNA methylation with repeated cell cycles (Nilsson et al., 2005).
It has been speculated that single nucleotide polymorphisms (SNPs) in DNA repair genes may change gene expression and activity, hence influence the effectiveness of cancer treatment and survival of patients [ 8].
Inferred from this observation, it has been speculated that these stable repressive marks may be related to DNA methylation recovery [36].
It has been speculated that they are under strong purifying selection, and may play important roles in DNA binding, RNA processing and transcriptional regulation [34].
It has been speculated that the anti-proliferative capacity of 1,25(OH)2D underlies its protective effect against UVB-induced DNA damage.
Thus, it is speculated that aberrant DNA methylation at imprinted DMRs is a key mechanism during malignant transformation of progenitor cells in a variety of tissues, including the liver [ 2, 9].
It is speculated that if repetitive DNA is transposable, it may create novel genes [62].
Thus, it can be speculated that siRNAs and DNA methylation are conducive to the maintenance of genome stability in AABB when faced with genomic shock in AB.
Thus, it can be speculated that part of the DNA found in blood is derived from CTC which could also explain the discrepancies in LOH patterns observed between blood and autologous tumor tissues.
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