However, it has been speculated that the local accumulation of uric acid in the kidney might be one of the mechanisms that causes CKD.
In particular, although it has been speculated that endocytic trafficking may be implicated in Patched and Smoothened localization, ciliary accumulation and signaling, the molecular mechanisms implicated in this process are poorly defined.
Accordingly, it has been speculated that the transient localisation of HP1 might be a prerequisite for the subsequent accumulation of HP1 in SAHFs (Zhang et al, 2005).
It has been speculated that serine-rich proteins, proline-rich proteins, and other polysaccharides are involved in Si accumulation [ 154].
Furthermore, it has been speculated that brain atrophy may lead to inappropriate brain re-expansion postoperatively and thereby create the potential for re-accumulation of the haematoma [ 4, 16].
Thus, it was speculated that the accumulation of activity into specific organ structures, yielding a local energy deposit for short-ranged electrons, might be the reason for the reduced impairment of renal function after therapy with short-ranged Auger/conversion electrons, as compared to treatment with the long-ranged β−-particles.
Thus, it was speculated that the accumulation of O-desmethyltramadol, combined with other pathways of action for tramadol, could provide analgesia, but the results showed no effect for tramadol.
It was speculated that the different accumulation levels of miRNAs in wild type and rdr2 mutants are caused by a secondary level of control by a siRNA-mediated pathway, which depends on RDR2/mop1 [ 41].
From this information it could also be speculated that the lack of starch accumulation in sugar beet tap-root could be due to high expression of genes for α-glucan or starch degrading enzymes.
Since rRNA binding is linked to nucleolar accumulation, it might be speculated that EBER-1 evolved to bind L22 during virus infection and prevent accumulation of L22 in nucleoli.
