In addition, the expression of genes implicated in signalling processes, cell adhesion and structure, protein modification, transport and metabolic processes is specifically regulated by treatment with EGF or shows a pronounced alteration in comparison with that in oestrogen-treated cultures (Fig. 1).
When a 2.5 fold expression cutoff was applied on the Mc52 sample, 1,918 of the regulated genes (32.1%) were specifically regulated at the merozoite stage, with 1,249 being upregulated and 669 genes downregulated at this stage.
There are 3,645 genes identified by either main effect or interaction effect, and 162 genes are specifically regulated under chimeric development, with a characteristic expression pattern that features continuous small differences between chimera vs. clone over development (Additional file 1: Figure S3).
We identified 1024 genes (955 genes were specifically expressed in ovules tissues when compared to others tissues) that were specifically regulated during these developmental stages, along with many highly stage-specific genes.
Some reports have shown that the deprivation of glucose is able to attenuate neurosphere formation efficiency but no neuronal maturation by human periodontal ligament-derived MSCs [ 46] and that glucose deprivation-induced necrosis, a distinct hallmark of the metabolic stress present in solid tumors in combination with hypoxia, is specifically regulated by Egr-1 [ 47].
Further, a different set of genes associated with ceramide synthesis was specifically regulated by and functionally involved in TLR4 signaling (Cers5, Cers2, Smpd4, and Ormdl3).
Our gene expression data demonstrated an equal percentage of genes to be specifically regulated during adipocyte and osteoblast differentiation (44%), with 12% of genes sharing a common profile in both differentiation lineages.
Thoreen et al. [ 14] confirm that mRNAs, which are specifically regulated by mTORC1, consist almost entirely of transcripts with 5′TOP motifs.
We identified 35 genes that are differentially regulated in patients with CLL compared with normal controls and 5 genes which may be specifically regulated by the MIR-15a/16-1 cluster at chromosome band 13q14.
To identify which genes were specifically regulated by SARS-CoV, we performed two sets of two-sample Student t-test for means with an unequal-variance assumption.
