Taken together, the data argue strongly that leishmania exosomal RNA sequences are specifically produced and packaged into exosomes for release, likely with the purpose of modifying host cell phenotype to support chronic infection.
Only the ESSENCE framework [ 11], however, had been specifically produced as a collaborative effort among funders.
A second key regulator of bone formation in humans is the secreted protein SOST, which is specifically produced by osteocytes and acts as a negative regulator of osteblast activity [16], [17].
The inhibitory cytokine IL-35 contributes to regulatory T-cell function, being specifically produced by Tregs and required for maximal suppressive activity [ 55].
We also reported that DHF patients with secondary infection, in contrast to DHF patients with primary infection, displayed higher serum levels of the MC-derived protein chymase, a biomarker that is specifically produced by MCs and associated with MC activation (St John et al., 2013b).
So-called 'bibibaff' rugs ('woven by ladies') were specifically produced for urban consumers and aristocrats, and are today valuable antiques [68].
ElpS is specifically produced under phosphate starvation and is associated with an increased secreted alkaline phosphatase activity when overproduced, Together, our data suggest that ElpS participates in phosphate mobilization.
IL-35 has been shown to be an inhibitory cytokine that may be specifically produced by Treg cells and is required for maximal suppressive activity [ 4].
Interestingly, others have reported that MMP-13 protein was restricted to small stromal foci within the tumor masses and was specifically produced by invading tumor cells [ 25].
24 25 sE-selectin is a member of the selectin family of carbohydrate binding lectins, and is specifically produced by activated endothelial cells.
