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Crystal structures of AChBP, a homologue of the nAChR ligand binding domain, have now been solved in complex with α-cobratoxin, α-conotoxin PnIA and α-conotoxin ImI.
While currently there is no three-dimensional structure for any full-length Janus kinase, the crystal structures of JAK2, JAK1 and JAK3 kinase domains in isolation have been solved in complex with specific inhibitors [10], [11], [12].
The structures of these helicases have been solved in complex with substrate DNA.
The crystal structure of the Anabaena NtcA dimer has been solved in complex or not with 2-OG [ 6].
The structure of GSK-3β has been solved in complex with different ligands, often surrounding an ATP analogue.
Escherichia coli MurG is an extrinsic membrane protein, for which a crystal structure has been solved, in complex with UDPMurNAc.
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Whereas no structures currently exist for this complex, the structure of the relevant Cul3 N-terminal domain has been solved in complexes with other homologous BTB-Kelch family members, including KLHL3 and KLHL11 [56], [56].
The crystal structure of the engineered FHA Myc-pThr-binding domain (Myc-pTBD) was solved in complex with its cognate ligand.
All these structures were solved in complex with the C-terminal eEF1Bα fragment and in some cases with GDP, GDPNP, or GDP-Mg2+ bound.
The yeast eEF1A structure used as a template in the current study was solved in complex with a fragment of eEF1Bα [38].
To gain insight into the structural basis of Gadd45a-RNA interactions we inspected the three dimensional structures of Gadd45 as well as of structures of other L7Ae members, which were solved in complex with RNA.
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