The performance of the compensator is analyzed using extensive computer simulations, and it is shown to virtually reach the perfectly matched reference system performance with low pilot overhead.
Interestingly, binding of the SV40 small t antigen to the PP2A AC dimer (thought to be tight) in place of the B regulatory subunit was shown to virtually inactivate the phosphatase towards most of its known substrates, and this effect are the basis for the oncogenic effects of small t antigen [26].
Indeed, although perhaps extreme, it has been stated that "TGFβ has been shown to mediate virtually all of the pathologic changes of diabetic kidney disease".
General Practice Research Database prescription data have been shown to be virtually complete, and the data on incidence of cancer (based on hospital records) are around 95% valid and complete.
In plants, most of them are targeted to mitochondria or chloroplasts and have been shown to control virtually all steps of organellar gene expression [ 26].
Among these physiological roles, miRNAs expressed by cells of the immune system have been shown to impact virtually all aspects of innate and adaptive immune responses [ 2].
Conversely, methotrexate has been shown to be virtually void from consistent adverse effects in the treatment of real-life patients with or without concomitant UDCA [ 38] while being burdened by significant side effects in randomized clinical trials [ 39].
Indeed, the three-dimensional ECM environment has been shown to affect virtually all aspects of cell behavior, including cell shape, proliferation, survival, migration, differentiation, polarity, organization, and branching.
In particular, cyclolignans can specifically and efficiently reduce the auto-phosphorylation, activity and hence downstream signalling of IGF-1R in different cell lines; furthermore, PPP has been shown to be virtually non-toxic in animal models (35, 36).
Moreover, one-time observations have been shown to have virtually no impact on faculty teaching, aside from influencing textbook selection (Spencer and Flyr, 1992), and may even lead to erroneous inferences (Weimer, 2002).
