Sentence examples for been shown to silence from inspiring English sources

In human cancer, aberrant methylation of promoters has been shown to silence genes; however, the relationship between DNA methylation changes and gene expression in normal individuals is less clear.

In Zebrafish, miR-430 [20] has been shown to silence maternal RNAs, miR-214 is involved in proper somite specification [21] and miR-375 is necessary for the maintenance of embryonic pancreas integrity [22].

One of the DNMT inhibitors, 5-aza-2'-deoxycytosine (5-aza-dC) has been shown to silence imprinted gene expression in mouse somatic cells by decreasing DNA methylation levels [15] and others have used this demethylating agent to improve SCNT [16] and iPS cell generation [17].

As hypermethylation of promoter regions has been shown to silence transcription [25] and to provide an alternative mechanism of inactivation of several genes [26], [27], [28], [29], we set out to investigate the methylation profile of the SGK1 promoter region in colorectal cancer cell lines and in normal and tumour colonic tissue samples.

SUV39H1 has been shown to silence S phase genes in terminally differentiating cells in cooperation with E2F/RB [ 46].

Furthermore, miR-29 has been shown to silence HIV-1 mRNAs that contain Nef sequences [ 49- 51].

Kaiso was shown to silence tumor suppressor genes in colorectal cancer [17], and its role in cancer was previously reviewed [18].

In somatic tissues, these endo-siRNAs were shown to silence TEs from where they originate in a negative feedback loop [4], [6].

Specifically, miR-30b/30d expression was shown to silence GALNT7, resulting in defective glycosylation and changes in protein exocytosis.

While the ability of lncRNAs to act locus-specifically to regulate a set of genes was first demonstrated for imprinted genes where lncRNA expression was shown to silence from one to ten flanking genes in cis[ 18- 20], lncRNAs that lie outside imprinted gene clusters, such as the HOTAIR lncRNA, were later found also to have locus-specific action.

A siRNA sequence (siPGC-1α) has been shown to effectively silence PGC-1α gene expression [40].