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Long term chemotherapy selection models have been shown to select for chemo-resistant tumor cells with increased DNA-PKCS expression/activity [ 34, 40].

The identification of variants that are unable to bind membrane receptor preparations (MRPs) has previously been shown to select attenuated yellow fever and Japanese encephalitis viruses.

Wild turkeys have also been shown to select nest sites in large patches with reduced edge density presumably to reduce the risk of nest predation (Thogmartin 1999).

Indeed, the use of hypoxia (3% O2) during the isolation step has been shown to select for a highly primitive hMSC-like cell population from the bone marrow with markedly improved self-renewal abilities [15].

This method has been shown to select sequences that are well bound by the H3/H4 tetramer but not necessarily by the full octamer.

GRP78/BiP has also been shown to select misfolded protein substrates with these co-chaperones.

This procedure has been shown to select for MSCs (Soleimani & Nadri, 2009).

Tumour hypoxia and anoxia have been shown to select for an aggressive subtype of tumour cells.

Avoparcin, which confers cross-resistance to vancomycin, has been shown to select for VRE in animals (Aarestrup et al. 1996).

Experimentally enforced monogamy has been shown to select for reduced investment in sperm production (i.e., decrease in testes size) relative to the polygamous condition [ 23, 26, 27].

Ewing sarcoma sphere growth under restricted serum conditions has recently been shown to select for cells that possess higher tumourigenicity (Wahl et al, 2010).