Here we say a physical interaction exists between two proteins if they have been shown to physically interact directly or indirectly as part of the same complex.
Stx18 has also been shown to physically interact with proteins involved in the cell cycle and apoptosis.
The highly conserved internal domain (Mcm10-ID) has been shown to physically interact with single-stranded (ss) DNA, DNA polymerase α, and proliferating cell nuclear antigen (PCNA).
Recently, three-dimensional ex vivo cellular cultures created through cellular self-assembly under natural extracellular matrix cues or through biomaterial-based directed assembly have been shown to physically resemble and recapture some functionality of target organs.
Fig. 4 Inhibition of PLK-1 reduces expression of mutant p53 protein in SW13 cells: Since PLK-1 has been shown to physically interact with p53 to control its functions; the levels of the p53 protein should not be affected after inhibition of PLK-1.
NR2E3 and CRX have been shown to physically interact in vitro through their respective DNA-binding domains (DBD).
Rad52 has been shown to physically associate with DSBs, which is thought to precede their repair by HR [54], [55].
Presenilins have been shown to physically interact with both of these channels and to influence their activity [14] [17].
Therefore, although GCR2 has been shown to physically interact with GPA1 [8], the exact role of GCR2 (and GCL1 and GCL2) in G-protein signaling remains unclear.
Yeast ASF1 has been shown to physically interact with Hir1, Hir2 and Hir3 and to interact genetically with Rad18 (http://db.yeastgenome.org/cgi-bin/interactions.pl?dbidS000003651).
Although the KKDC peptide has been shown to physically interact with heparin and HS [29], binding and localization at the cellular level have not been so far demonstrated.
