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In addition, GPCRs have also been shown to functionally regulate ion channels and help fine-tune neurotransmission.
Functional electrical stimulation is a technique that has been put into practice for several years now, and has been shown to functionally restore and rehabilitate individuals with movement disorders, such as stroke, multiple sclerosis and traumatic brain injury, among others.
The constructs are fusions of Lim domain binding protein 1 (Ldb1) and Lhx1, which had been shown to functionally replace Lhx1 in depletion and over-expression assays [23].
GPNMB/OA is also readily detectable in immune cells, such as macrophages and dendritic cells [5], [6], and has been shown to functionally impair T-cell activation [7], [8].
Motifs have been shown to functionally implement signal processing within larger networks [ 81, 82].
The HPC has been shown to functionally interact with both the PRH and mPFC during object-in-place memory performance.
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The transcription factors Stat3 and FoxO1 (Figure S4A) are involved in the regulation of POMC gene expression, and both were shown to functionally interact with Sirt1 [29], [29].
However, we believe this scenario is unlikely since several heterologous sigma factors are shown to functionally interact both in vivo and in vitro with E. coli RNA polymerase [37], [38], [39].
Osteoblasts were shown to functionally contribute to this confined niche.
Both human CTP synthases were shown to functionally complement yeast mutants lacking CTPS.
MtZIPs were shown to functionally complement yeast metal-uptake defective mutants [ 34].
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