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Activated macrophages have also been shown to enforce phagolysosomal fusion, which is otherwise inhibited by the pathogenic mycobacteria.
Contrastingly, CR in E. coli has recently been shown to enforce symmetrical cell division while prolonging longevity (Lele et al. 2008), although it is possible that CR simply reduces oxidative damage and protein aggregation below a detectable limit.
A gene significantly methylated and repressed in 'pan- HOXA' tumors only was PHF23, a frequent fusion partner with NUP98 in acute myeloid leukemia (AML) that has been shown to enforce HOXA9-10 expression by protecting activating H3K4Me3 marks and blocking EZH2 mediated HOX-gene repression [ 35].
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Indeed, p21 protein has been shown to inhibit phosphorylation of Cdc2 and to enforce G2 arrest (Smits et al, 2000).
Experimentally enforced monogamy has been shown to select for reduced investment in sperm production (i.e., decrease in testes size) relative to the polygamous condition [ 23, 26, 27].
Research on policies enforcing land privatization has been shown to have negative effects on the social well-being of women.
Enforced periods of no email or internet to allow us to sustain concentration have been shown to be tremendously helpful.
HARP was shown to signal through enforced dimerization of RPTPβ/ζ which, in turn, results in a loss of the RPTPβ/ζ catalytic tyrosine phosphatase activity.
Recently, the microrchidia (MORC -type ATPases were shown to play essential roles in enforcing transcriptional gene silencing of a subset of genes and transposons by regulating the forMORC -typehigher-order chromATPaseschitecture.
This algorithm is shown to satisfy Gauss's law and enforces no magnetic monopoles while maintaining a globally second-order result (first-order at physical boundaries), with no added time-step restriction.
In other studies, enforced Bcl-2 expression was shown to inhibit several key mechanisms of immune killing, including those initiated by granzyme-B, FasL and TRAIL (Pinkoski et al, 2001; Raisova et al, 2001; Fulda et al, 2002; Guseva et al, 2002; Velthuis et al, 2002).
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