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This is a 'bias-correction' solution that has been shown to correct for remaining finite sample bias, while potentially also making violations of functional form assumptions less consequential [35, 36].
Traditional RNA-DNA chimeric oligonucleotides (chimeraplasts), composed of a continuous stretch of RNA and DNA residues in a duplex conformation, have been shown to correct single-base mutations in episomal and genomic DNA both in vitro and in vivo.
Parallel RF transmission using tailored 3D k-space trajectory design has been shown to correct for this problem and produce highly uniform in-plane magnetization with good slice selection profile within a relatively short excitation duration.
Clozapine, but not conventional antipsychotics, has been shown to correct some of these deficits.
CO2 removal systems used in conjunction with non-invasive or protective ventilation strategies have been shown to correct pCO2 and pH in hypercapnic patients with removal rates equivalent to ~ 25 35% of the metabolic CO2 production (~ 200 250 mL/min) [22, 23].
Functionally, RNA editing has been shown to correct for frameshift mutations, form initiation codons and create entire ORFs [4] [6].
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To our knowledge, this is the first time that an U1 snRNA variant is shown to correct exon skipping due to polypyrimidine tract and exonic mutants.
Carnitine supplementation (50 mg/kg per day) for 4 weeks was shown to correct both carnitine deficiency and hyperammonaemia in 14 VPA-treated patients [ 38].
Notably, drugs that are being developed for cancer, such as 4EGI, were shown to correct autistic-like deficits in mice [ 115] and cercosporamide reversed many of the FXS-like symptoms in mice [ 116].
In a multicenter, placebo controlled study, PEG was shown to correct bowel movements also in IBS adult patients with constipation, but with no significant effects on digestive symptoms [ 72].
More recently, the Hh pathway agonist SAG1.1 was shown to correct some of the structural and cognitive deficits seen in the Tg65Dn mouse model of Down syndrome (Das et al., 2013).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com