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These two latter PDT outcomes are of particular interest as certain promising anticancer regimens have been shown to concomitantly activate ER stress and autophagy.
17 Consistent with such findings, immunotherapy intended to reverse the accumulation of Aβ plaques in the brain has been shown to concomitantly increase cerebrovascular Aβ and exacerbate microvascular lesions.
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These observations suggest that SVZdNP take part to the important reactive astrogliogenesis that has been shown to occur concomitantly to oligodendrocyte loss in the cuprizone model (Skripuletz et al., 2011).
The identification of an Oct2 binding motif within unique PU.1 regions implies a potential co-activator role, as PU.1 and Oct2 have previously been shown to bind concomitantly at the Vκ19 promoter in B lymphocytes, and point mutations in the binding sites for either factor can lead to diminished immunoglobulin production [ 43].
Furthermore, the inactivation of SKP2 through the regulation of abundance or activity has been shown to restrict tumorigenicity concomitantly with p27 accumulation.
The pan-caspase inhibitor zVAD-fmk has been shown to inhibit apoptosis and concomitantly foster necroptosis.
Synovial fibroblast IL-6 production has been shown to inhibit bone formation and to concomitantly stimulate bone resorption and pannus formation [ 40].
RAGE expression is widespread in the retinal neuropile of rats and mice, being especially high in the Müller glia [ 4], and it has been shown to increase in diabetic rats concomitantly with ligands such as AGEs and S100b [ 6, 29].
Indeed, UCN-01 has been shown to downregulate Akt activation (but concomitantly stimulate ERK1/2) in head and neck squamous cell carcinoma (Amornphimoltham et al, 2004; Kondapaka et al, 2004).
The extent of pharmacokinetic enantioselectivity has been shown to be species-specific and dependent on drugs concomitantly administered [ 7].
When used concomitantly with warfarin, efavirenz has been shown to both increase and decrease warfarin levels and INR.
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