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In accordance, it has been shown that sustained T cell activation and proliferation require antigen presentation by migratory DCs [35] and that the entrance of blood-derived, inflammatory DCs into LNs depends on CCR2 [36].
It has indeed been shown that sustained stimulation induces, after a short transient, a switch to different stationary states for metabolism, neuronal activity, and hemodynamic responses [ 39- 41].
It has been shown that sustained morphine treatment of rats, leading to analgesic tolerance, did not change the density or G-protein coupling of the surface mu-opioid receptors.
Recently, it has been shown that sustained hypoxia (FiO2 = 1.0% for 2 h) increases the expression of Hsp 70 family, Hsp68 and Hsp23.
Dealing with the time course of attentional effects, it has been shown that sustained attention can influence processing tasks as early as 60 ms after the onset [13].
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Using the decomposition method of analysis, it was shown that sustained serious injury rates of the younger driver group (30 to 50 years) was less than half that of the older driver group (above the age of 70) [30].
It has been shown that sustaining higher levels of C-peptide secretion is associated with fewer microvascular complications of diabetes and fewer episodes of hypoglycemia (22).
Little is known of intracellular signalling networks that support ductal branching; however, in a pubertal mammary explant culture it was shown that sustained ERK1/2 activation induced by TGFα caused branching, while transient ERK1/2 activation induced by FGF7 did not.
In support of this, it has been shown that mitochondria can sustain a certain degree of insult before there is any change in membrane permeability, which is the determining factor in cytotoxicity (Zorov et al., 2006).
Although it has been shown that disc cells sustain a phenotype in culture, the fate of re-implanted cells is not fully understood.
It has been shown that the uncontrolled and sustained inflammatory cascade, observed in IBD, gives rise to the production of MMPs and TIMPs which in turn can induce tissue degradation and lesion development [ 1, 2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com