Sentence examples for been shown that statins from inspiring English sources

Furthermore, it has been shown that statins have a biphasic effect on endothelial cell migration, promoting the response at low concentrations, and inhibiting it at high concentrations [18].

It has been shown that statins exert not only anti-lipid, but also marked anti-inflammatory effects [ 9].

It has been shown that statins can reduce liver triglyceride [ 11] and ameliorate severe hepatic steatosis [ 12], thereby improving NASH-related fibrogenesis.

This might eventually be because a large proportion of the patients were already on statin therapy or received it during the study (45% at follow-up) as background medication, and it has been shown that statins contribute to stroke prevention.

It has also been shown that statins potentiate eNOS activity by decreasing Cav-1 abundance in vitro and in vivo, at least in macrovascular endothelial cells where the caveolin pool is lower and the proportion of caveolin-bound eNOS is higher [ 19] (see also review in [ 4]).

In humans, RAGE overexpression has been associated with enhanced inflammatory reactions at the vulnerable region of the plaque in carotid endarterectomy specimen [ 32] In an intervention study it has been shown that statin treatment prior to carotid endarterectomy reduces inflammation as well as RAGE expression [ 33].

It was shown that statins decrease death among certain cases.

12 In a retrospective study conducted in the US, 69 it has been shown that lower statin titration rates are required for patients initiated on rosuvastatin treatment than for those in whom treatment with other statins has been initiated.

Similarly, it has been shown that, in fact, statins also reduce portal pressure in humans and improve liver function [ 151].

Furthermore, it has been shown that short-term statin treatment in certain cardiovascular settings result in demonstrable improvement in outcomes [23] [25].

For instance, it has been shown that the use of statins is negatively associated with complicated plaque features [27], whereas the use of antiplatelet therapy can decrease WML progression [28].