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It has been shown that serum MMP-3 levels are elevated in patients with inflammatory arthritis compared with healthy controls [27] [30].
It has also been shown that serum half-life prolongation of therapeutic antibodies may improve clinical outcomes, and may reduce the amount of antibodies required [27].
The levels of expression of HCMV proteins were assayed with a HCMV antibody-positive serum since it has been shown that serum from patients with CMV infection reacts with a large number of structural virion proteins [25].
This could have important medical implications in terms of the treatment of sepsis, as it has been shown that serum VEGF levels (known to be regulated via HIF-1) are dramatically increased in patients suffering from septicemia [30] or meningitis [31].
Also, it has been shown that serum stimulation leads to activation of MAP kinase pathways [ 54].
It has been shown that serum bile acids are elevated in patients with NASH and increase with disease progression [ 16].
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It has been shown that serum-starved 5637 cells promote tyrosine phosphorylation and activation of EGFR (Fig. 3) (Yamamoto et al., 2006) through autocrined secretion of EGF and/or EGF-related ligands (Ruck and Paulie, 1998).
It was shown that serum levels of OPN were significantly higher in patients with active VKH disease than in patients with inactive VKH disease and in the control group [[110]].
Interestingly, it was shown that serum visfatin is significantly elevated in patients with gastric carcinoma and BC and may be a promising biomarker for colorectal adenocarcinoma [ 22].
In a study of patients with rheumatoid arthritis, it was shown that serum IL17 levels were decreased after treatment with adalimumab and methotrexate [ 17].
It was shown that serum hyaluronate increase in alcoholic liver disease [ 5, 20, 35], primary billiary cirrhosis [ 19] and in patients with hepatitis C [ 12, 36].
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