Sentence examples for been shown that prolonged from inspiring English sources

For example, it has been shown that prolonged extracorporeal circulation (over 2 h) is a major risk factor for AKI during cardiac surgery.

It has been shown that prolonged ischemia causes membrane depolarization in sensory nerves, correlating with a "paradoxical" reduction of K+ currents by increasing intracellular acidosis [27]; however, those findings are still a matter of discussion and need further exploration.

It has recently been shown that prolonged in vitro culture of hESCs is associated with DNA methylation instability [14], [15].

Moreover, it has been shown that prolonged fast respiration (>4 Hz) reduces odor-evoked Ca2+ signals in OSNs (Verhagen et al., 2007).

While the short-term effect of lysosomal inhibition on mTOR activity state is undetermined, it has indeed been shown that prolonged (overnight to 24 hours) lysosomal inhibition by BAF [ 38] or the lysosomotropic agent chloroquine [ 16] results in mTOR inactivation.

It has been shown that prolonged systemic presence of a drug can cause a build-up of that drug in the skin.

Future studies that use hormones to induce metamorphosis at different times during ontogeny may be able to disentangle the effects of aging from intrinsic regenerative ability, as it has already been shown that prolonging the larval state enhances regenerative ability compared to same-aged animals that have undergone metamorphosis [ 13].

It has been shown that during prolonged fasting, GHSR expression in the hypothalamus is increased, which could contribute to the amplification of ghrelin action [28] and could be expected to result in a ghrelin-independent increase in receptor signalling and thereby an increase in appetite [7].

While expression of BR-3 on plasmablasts is lower than on naive B cells, it has been shown that BAFF can prolong the survival of plasmablasts (16, 17, 33).

Since it has been shown that SU can easily cause prolonged hypoglycemia and weight gain, they have to be used with caution in the early stages of T2DM. 11, 11 Although glinides are insulin secretagogues that bind to the SU receptors of pancreatic β-cells as well, they can facilitate rapid insulin secretion, restore postprandial early insulin secretion, and reduce the postprandial glucose spike.

In addition, it has also been shown that under conditions that cause prolonged release of low amounts of ATP, this nucleotide has a more subtle modulatory function, inducing a distorted DC maturation and diminishing the ability of mature DCs to initiate type 1 immune responses.