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Mechanistically, it has been shown that persistent ATM activation is necessary for induction of the SASP (44).
It has been shown that persistent fatigue can lead to health problems, impaired performance during work, and a decreased work-private life balance.
It has been shown that persistent angina symptoms are associated with long-term anxiety, depressions, impaired physical functioning and QOL [ 3].
It has been shown that persistent microcirculatory alterations are associated with organ failure and mortality in patients with septic shock [ 2].
This might be of importance since it has been shown that persistent LBP at an early age in particular is a strong predictor of persistent LBP later in life [ 5].
When it turns out that no metabolizable nitrogen sources are present, the PKA pathway and the growth machinery will be down-regulated again, since it has been shown that persistent activation requires active metabolism [ 15].
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It has been shown that the persistent presence of myofibroblasts appears to be a primary driver of the progression of fibrosis in IPF [ 45].
More recently, it has been shown that having a persistent limiting longstanding illness (LLI) from early adulthood was associated with being a persistent nondrinker from the early 20s to the 40s (Ng Fat et al., 2014).
It has been shown that the majority of persistent spines predominantly forms functional synapses with presynaptic boutons [52].
It has been shown that there are more persistent alterations of HIF-1 α expression when hypoxia is accompanied by ischemia.
It has been shown that the global HMF has persistent active longitudes whose dominance depicts an oscillation with a period of about 3.2 years.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com