Sentence examples for been shown that mutant from inspiring English sources

It has previously been shown that mutant splicing factors, for which the mutation decreased their affinity to the target RNA motif in vitro by a factor of five, had reduced splicing activity in cells42,52.

In addition, it has been shown that mutant ATXN7 protein recruits wild-type ATXN7 into intracellular inclusion-like aggregates [28].

It has been shown that mutant p53 triggers different pathways that represent the molecular basis of the gain of function activity [52].

It has also been shown that mutant SOD1 augmented AMPA receptor permeability to Ca2+ [162].

It has also been shown that mutant EGFRs selectively activate signalling pathways that promote cell survival (Salomon et al, 1995).

In some situations, it has been shown that mutant cells can become 'supercompetitors' and behave as winners by outcompeting wild-type cells, which now turn into losers.

It has recently been shown that mutants lacking a region in the N-terminal domain of Fps1p constitutively release glycerol.

Recently it has been shown that mutants of poliovirus resistant to either HBB or guanidine exhibit only a small degree of reciprocal cross-resistance5,6 Combined treatment with HBB and guanidine was, therefore, expected to have a greater suppressive effect on virus reproduction than either compound alone.

Indeed it has been shown that mutants in FtsZ that have slowed GTP hydrolysis kinetics also have a slower turnover rate inside the living cell [ 67].

Moreover, it has been shown that mutants lacking genes encoding efflux pumps still retain their resistance to antifungals when grown in a biofilm.

For example, it has been shown that mutants of E6, defective in their ability to induce the degradation of p53, can still immortalize human embryonic cells (Ishiwatari et al, 1994; Nakagawa et al, 1995).