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It has been shown that miRNA profiles are surprisingly informative.
It has later been shown that miRNA molecules are essential for the proper development of cardiovascular system [ 26].
It has previously been shown that miRNA let-7b downregulates MMP9 activity through indirect effects by inhibition of basigin.
Also, it has been shown that miRNA pathways control important steps during the developmental timing of retinogenesis [ 17], and appear to regulate neuronal differentiation [ 18].
It has been shown that miRNA export into exosomes occurs via the ceramide-dependent secretory pathway and independently of the endosomal sorting complex required for transport (ESCRT) [ 24].
It has also been shown that miRNA expression may predict tumour grade and therefore recurrence or progression (Gottardo et al, 2007; Catto et al, 2009; Neely et al, 2010).
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Precious studies have also classified miRNAs, for example, into families [67], but it has been shown that miRNAs can evolve rapidly [36, 37, 66], which is detrimental for their categorization into families.
It has recently been shown that miRNA-34a is also downregulated in tumors of peripheral nerves called malignant peripheral nerve sheath tumors (MPNST) where it may act as a tumor suppressor as well [24].
It has been shown that miRNAs are generally down-regulated in cancer [8].
It has been shown that miRNAs accelerate the degradation of their target transcripts and repress their translation.
Recently, it has been shown that miRNAs may act as oncogenes and tumor suppressors by targeting key regulators of cell growth [23] [25].
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