Interestingly, it has been shown that low levels of Dorsal can act synergistically with bHLH proteins to activate target genes in the embryo [34].
However, it has also been shown that low levels of NO stimulate mitochondrial proliferation, suggesting that effects of NO on mitochondrial function during sepsis depend on its concentration and the timing of its release [ 35].
This could explain the increased DNA fragmentation, especially as it has been shown that low levels of caspase-3 activity is enough to induce apoptosis in these cells (Johansson et al, 2008).
Recently, it has been shown that low-level gene copy number change is associated with changes in expression level of its transcripts [ 12].
For example, it has been shown that low-level grazers often possess a suite of cranial characteristics that allow them to efficiently crop short grass, including wide, ventrally deflected muzzles, elongate faces, transversely wide paroccipital processes, deep mandibles, and tall withers [ 142- 150].
It has been shown that low SOD levels in RA patients, increased after NSAID treatment and reached normal levels [34].
It has recently been shown that low serum levels of the molecules sclerostin 10 and Dickkopf 1 (DKK1), 32 which are both important for osteoclast activation and osteoblast inhibition, are associated with the formation of new syndesmophytes in patients with AS.
It has been shown that low sugar levels in male-sterile anthers may be related to reduced amylolytic activity, i.e. the breakdown of starch in the stamen, as in a male-sterile mutant of tomato (Bhadula and Sawhney, 1989).
In B-cells it was shown that low sustained levels of elevated [Ca2+]i activates NFAT (Dolmetsch et al., 1997), and a similar [Ca2+]i-calmodulin-calcineurin-NFAT pathway was subsequently suggested for the excitation-transcription coupling in muscle (Chin et al., 1998).
It was shown that low plasma adiponectin levels are significantly correlated with endothelial dysfunction, increased intima media thickness and progression of coronary artery calcification independently of other cardiovascular risk factors [ 18, 19].
It has been shown that relatively low levels of innervation can produce a grade 4 contraction and that its sensitivity is better in the range of 0 to 3 grades and for diagnosis of nerve deficits [ 41, 42].
