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Recently, it has been shown that extensive de novo and recurrent CNV occurs in vitro in mouse embryonic stem cell lines derived from common parental lines, leading to mosaic animals containing variants of the zygote genome [12].
Interestingly, it has been shown that extensive DNA damage induces necrotic cell death in a Poly(ADP-ribose) polymerase (PARP) dependent manner.
Importantly, it has been shown that extensive clonal diversity exists for point mutations within the same breast tumor mass, in contrast to structural chromosomal changes [ 19].
While it has been shown that extensive carbapenem use may lead to increases in resistance [ 16, 17], in some studies imipenem-based empiric strategies did not lead to higher rates of bacterial and fungal superinfections [ 18, 19].
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However, in dengue-endemic countries, it has been shown that, despite extensive vector control efforts, outbreaks of dengue still occur and the number of cases remains high.
Similarly, it has been shown that specific and extensive practice can lead to neural economy of motor preparation and modification of elementary visuo-motor functions [35], [47].
It has been shown that even after extensive FFP transfusion, declining fibrinogen levels persisted in PPH patients.
In fact, it has been shown that even with extensive UV and bleach treatments, it is impossible to completely remove modern human DNA from ancient bones and teeth [ 92].
It has been shown that the incorporation of extensive upper abdominal procedures such as diaphragm peritonectomy, splenectomy and partial liver resection increased successful cytoreductive outcomes and consequently significantly improves survival (Chi et al, 2009).
Because it has already been shown that there can be extensive horizontal gene transfer within the actinomycetes [ 27, 28], and that genome-based trees can differ from 16S and concatenated gene trees [ 29], we tested for recombination in the data set using the PHI test implemented in SplitsTree (p=1.0).
For mouse, it has been shown that X and Y chromosomes display extensive side-by-side pairing early in meiotic prophase, which decreases in length as meiotic prophase progresses [56].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com