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It has been shown that endogenous and overexpressed BIG1 colocalize with the clathrin adaptor AP-1 on the TGN.
As expected, only trace amounts of TG2 were found in the nucleus with the untagged TG2 transfected cells (Fig. 1b), as it has previously been shown that endogenous or exogenous TG2 is mainly cytoplasmic [32].
It has been shown that endogenous attentional control has a larger impact on the sensitivity for detecting a target presented with noise or distracters than for detecting one presented alone [5], [22], [33].
It has furthermore been shown that endogenous PrPC is associated with exosomes released by blood platelets [33], and a number of studies have demonstrated that prions are present in blood and blood components, buffy coats, plasma, and platelets in animal models [34], [35].
It has been shown that endogenous ligands, and especially the opioid peptides, are expressed by resident immune cells in inflamed peripheral tissue.
For example, it has been shown that endogenous p73 is activated in response to a variety of chemotherapeutic drugs in a c-Abl-dependent manner [ 68, 74, 81].
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In muscle cells and the hepatic cell line Hep2, it was shown that endogenous β1-syntrophin protein levels were reduced after transfection with miR-222 and that the inhibitory effect of miR-222 was blocked in the presence of anti-miR-222, which then restored β1-syntrophin protein expression to normal.
In postmenopausal women on dialysis, who have a high risk for developing mineral and bone disorders, it was shown that endogenous estrogens may prevent bone loss [ 37].
It was shown that endogenous dammarenediol synthase protein was obtained by prokaryotic expression and analyzed the correlation of the DS activity and the accumulation of dammarenediol by LC-MS.
Subsequently, it was shown that endogenous oestrogens or human milk-fat extracts, known to contain organo-chlorinated and brominated xenobiotics, markedly enhanced B[ a]P-induced genotoxicity in clonogenic MCF-7 cells (Davis et al. 2002; Kalantzi et al. 2004a).
In addition, it has been shown that exogenous and endogenous prostaglandins (PGs) modulate both bone formation and resorption [ 19- 23].
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