Although the treatment effects of radiation for this application are primarily the result of the direct destruction of tumor cells, it has recently been shown that the effectiveness of radiotherapy could partially be explained by the inhibition of osteoclastic activity [ 11].
In addition, it has been shown that the effectiveness of continuous immunotherapy may be counteracted by large numbers of immunosuppressive cells in the tumour microenvironment (Stewart et al, 2004), or the induction of functionally corrupt memory T cells (Klebanoff et al, 2006).
So far it has been shown that expectations about effectiveness of a certain treatment enhance the effectiveness of different analgesics and of drug-free pain treatments.
It has been shown that to achieve effectiveness of antiviral treatment, therapy should be initiated within 48 hours of the onset of clinical symptoms [11], [12].
It has been shown that the antitumor effectiveness of the combined treatment with IL-12 and tumor irradiation depends on the presence of T and NK cells [ 8], both of which are stimulated by IL-12.
Since it has been shown that seasonal influenza vaccine effectiveness is higher in adults than in elderly persons and children [15] [17], we also assumed that both pandemic and pre-pandemic vaccine effectiveness would vary by age.
It has been shown that monensin significantly improves the effectiveness of the traditional antidote DMSA (dimercaptosuccinic acid) in reducing Pb II) concentration in brain and bones of rats, intoxicated with a Pb II) salt [34].
Finally, it has been shown that experimental results successfully demonstrate the effectiveness of the proposed control system for four-axis position synchronous control.
Apart from their anti-inflammatory properties, it has been shown that one important mechanism accounting for the effectiveness of intravitreous steroidal drugs is the inhibition of both VEGF synthesis and downstream receptor signaling (36, 38).
Regarding cost-effectiveness, it's been shown that virtual colonoscopy is less than half the cost of the optical test.
