It was shown that differentiated cells, especially in the organism, are indeed locked by CDK inhibitors [ 40, 41].
It has been shown that poorly differentiated lung adenocarcinoma and squamous cell carcinoma expressed lower levels than well-differentiated and moderate-differentiated cancers [ 20].
This evidence has been observed for breast cancers, where it has been shown that poorly differentiated, more aggressive tumors (histological grade 3) have an increased number of CSCs than well differentiated (histological grade 1) tumors (Pece et al, 2010).
It has previously been shown that newly differentiated cardiomyocytes from cardiac progenitors cells can be identified by their expression of unfolded DsRed protein in their cytoplasm [26], [27].
It has been shown that the prevalence of poorly differentiated gastric carcinomas is higher than well differentiated gastric cancers (Nakamura et al, 1999).
It has also been shown that many genes specific to differentiated hematopoietic lineages are expressed in hematopoietic stem cells [44].
It has been shown that viable tumour can be differentiated from necrotic tumour with DW-MRI in the larynx [ 39].
Whereas the identity and source of Wnt ligands that signal to T cells in vivo remain to be elucidated, it has been shown that macrophages and in vitro-differentiated dendritic cells can produce Wnt7b and Wnt5a, respectively, and that multiple Wnt transcripts including Wnt1, 2B, 4, 5A and 8B are detected in vascular endothelial cells.
While it has been shown that cells resembling PGCs can be differentiated from ESCs in vitro, to our knowledge, the current investigation is the first to characterize PGC-like cells generated from the induced differentiation of somatic-derived stem cells.
By applying special stains and electron microscopy it has been shown that many cases of LCC are poorly differentiated ADC or SCC (http://www.ncbi.nlm.nih.gov/books/bv.fcgi rid=cmed.section.20772).section.20772
