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It has been shown that combination therapy is superior to monotherapy with biologic agents in inflammatory bowel disease, but the optimal dose of IM in combination therapy has yet to be examined in a prospective study.
It also has been shown that combination of complete small molecules promoting cell reprogramming can convert somatic cells into intermediate cells.
It has been shown that combination random walks such as composite Brownian walks may have a higher search efficiency than Lévy motion and composite, two-search mode walks (referred two-search modeent search models [24]) can generate patterns that look similar to Lévy motion [20], [24].
Although TRAIL induces apoptosis when given alone, it has been shown that combination of TRAIL with cytotoxic drugs as 5-fluorouracil, etoposide, paclitaxel, actinomycin C and cisplatin has an even higher apoptotic efficacy [ 50- 59, 6].
Indeed, it has been shown that combination of trastuzumab with standard chemotherapy is associated with significantly improved survival following development of CNS metastases in BC patients compared to patients receiving standard chemotherapy only [ 5].
That would help design individualized clinical trials to tease out the full effects of MMP inhibition since it has been shown that combination therapy of MMP-14 inhibitor with chemotherapy prolonged survival of GBM patients while Marimastat alone had no benefit in recurrent GBM 42.
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It has been shown that combinations of desirable properties can be achieved by the partial crystallisation of glass-forming alloys, either during controlled solidification or by annealing a fully amorphous glass.
It has been shown that combinations of lipases can favour the process since different lipases have different substrate specificity [ 16, 22].
It was shown that combination of experimental and computational approach can be successfully applied for the selection and design of suitable ionic liquids for efficient extraction of various polarity pesticides using simple aqueous biphasic ionic liquid based systems.
It was shown that combination of silica support and a small amount of cerium/manganese oxides allows developing silver catalysts with defined micro- and macrostructure as well as high activity in the total oxidation of formaldehyde.
It is shown that combination with two approaches to realize complicated models of building HVAC system for the application of model-based fault detection and diagnosis is a good solution.
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