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It has been shown that brain plasticity depends also on the modulation of nicotinic receptors, BDNF polymorphisms and sex hormonal variations[35, 36].
Similarly, it has been shown that brain areas designed for the processing of audio signals and speech can be used for visual tasks, such as people born with hearing impairments who can re-purpose the audio/speech area of their brains to process sign language.
Indeed, it has been shown that brain and peripheral nerve pericytes can contribute directly to vessel wall barrier function via pericyte-pericyte junctions [41].
In support of this hypothesis, it has been shown that brain samples from Mecp2-deficient mice display reduced spontaneous synaptic transmission as well as reduced synaptic plasticity molecular processes that underlie synaptic formation, learning, and memory [ 47].
It has been shown that brain, especially neurons, synthesizes E2 de novo from cholesterol, but circulating E2 or precursor hormones also penetrate through the blood brain barrier (Kancheva et al., 2011).
It has been shown that brain has the smallest mRNA expression differences between species, and it was concluded that purifying selection is extremely efficient at eliminating mutations that modify gene expression in this tissue (Khaitovich et al. 2005, 2006).
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It has been shown that brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine receptor kinase B (encoded by NTRK2) regulate eating behavior and energy balance.
As one prevalent phenomenon in neurons, it has been shown that brain-enriched miRNAs tend to co-express with their target genes, which also exhibit brain-specific expression [ 50].
It was shown that brain was the organ that expressed the most abundant ANP32A, followed with heart, liver, and kidney.
In this study, it was shown that brain was the organ that expressed the most abundant ANP32A by human multiple tissue expression (MTE) array.
It was shown that brain tumours show differences in IDO (the enzyme converting Trp to kynurenine) expression and that this expression was related to the amount of AMT taken up by the tumour [ 94].
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