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It has been shown that altering the propagation of the salt and temperature waves in a proper manner allows improving the separation efficiency.
Furthermore, it has been shown that altering the androgen-estrogen balance can affect adult male accessory sex organs because exogenous estrogens directly stimulate epithelial proliferation resulting in aberrant histological changes and even prostatic squamous metaplasia (26, 27, 28, 29, 30, 31, 32).
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For other neoplastic diseases, it has been shown that altered cytokine levels contribute to alterations of physical and psychological well-being, 15 which may be the case in patients with MDS/leukemia; 16, 17 in polytransfused patients the evolving secondary hemochromatosis may also contribute to the number of symptoms MDS patients have to bear.
It has been shown that altered PEP activity is associated with various psychological diseases such as schizophrenia, mania and depression.
Using a model study, it has been shown that altered mitochondrial function may contribute to the development of an arrhythmogenic substrate in the heart, but very little is known about its effects on the electrophysiological properties of the heart.
It has previously been shown that altered Ca2+ levels have dramatic effects on hair cell function and mechanotransduction (Beurg et al., 2010; Ceriani and Mammano, 2012; Ohmori, 1985; Tanaka et al., 1980).
First, it was shown that altered peptide ligands could be used to influence the quality of a primed T-cell response through a process called TCR-optimised peptide skewing of the repertoire of T cells (TOPSORT).
In a recent study examining the spring-like behaviour of centromeres, it was shown that altering chromatin higher order structure by lowering levels of a core histone causes an increase in the 'rest length' of the spring (i.e. the distance between sister kinetochores when the centromere is not under load) (Bouck and Bloom, 2007).
It has been shown that formalin alters bone and soft tissues by crosslinking the proteins without altering the secondary structure (Wilke et al. 1996, Burkhart et al. 2010).
It has been shown that Nrf2 alters miR-1 and miR-206 levels via modulation of ROS contents.
It has been shown that hyperglycemia alters the tight control of intracellular calcium dynamics in retinal cells and may lead to the development of diabetic retinopathy [ 97].
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