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Increased levels of immune complexes of hypocretin-1 IgG autoAbs especially reported in NC may signify deficient hypocretin signalling as has been shown recently for α-melanocyte-stimulating hormone (α-MSH) autoAbs [26].

The discovery of two modes of response has also been shown recently for protein dynamics to a drug perturbation where a rapid translocation of specific proteins and a slower, wide-ranging temporal wave of protein degradation and accumulation occurred [34].

Independently of apoptotic events, vimentin can be actively secreted and exposed on the extracellular side of the plasma membrane as it has been shown recently for activated macrophages [48].

Such an approach has been shown recently for the discovery of glucuronosyldiacylglycerol lipids (GlcADG) from phosphorus depleted plants.

It is possible that these effects may pass through generations as has been shown recently for sperm cells".

First, H5N1 virus infection may threaten the survival of endangered felids, as has been shown recently for other emerging viruses in susceptible wildlife (19, 20 ).

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Another possibility is that some secretory proteins are released by alternate, poorly characterized secretory pathways, and would therefore be missed by searching for secretory peptide sequences, as was shown recently for B. malayi secreted proteins [ 23].

It will also be interesting to determine whether the −174 C allele is a risk factor for breast cancer, as was shown recently for colorectal cancer (Landi et al, 2003).

It is possible that rather than promoting repair, the BRCA1 ubiquitin ligase functions as a negative regulator of double-strand break repair, as was shown recently for the ubiquitin-binding RAP80 complex (Coleman and Greenberg, 2011).

In some cases, they can even produce complex mutations (e.g. tandem base pair substitutions and clusters of multiple, closely spaced mutations) as was shown recently for Pol ζ (Stone, Lujan, Kunkel 2012).

A high proportion of S96 cells in S phase suggests that a density-dependent slowdown of DNA synthesis and subsequent S phase arrest was a major mechanism responsible for reduction in proliferation in undifferentiated P19 EC cells, as was shown recently for mouse ES cells (Jirmanova et al. 2005; Andäng et al. 2008).

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