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This is a significant development and is the first time this phenomenon has been shown in solid tumours.
25, 8 The existence of some slow-growing cancer cell populations has also been shown in solid tumors such as breast and liver cancers.
The expansion of myeloid-derived suppressor cells (MDSCs) and its correlation with advanced disease stage have been shown in solid cancers.
This phenomenon has not been shown in solid tumours until the recent publication by Al-Hajj and colleagues where they describe a method for differentiating 'tumour-initiating' or 'tumourigenic' breast tumour cells from non-tumourigenic cells [ 4].
Overall, the results suggest that, in analogy to what has already been shown in solid tumours, angiogenesis occurring in B-NHLs increases with tumour progression, and that macrophages promote the induction of angiogenesis via the release of their angiogenic factors.
The upregulation of this protein has been shown in solid tumors and hematologic malignancies, and therefore, inhibition of the mTOR protein can limit malignancy growth for patients refractory to other treatments [ 53].
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The experimental data are shown in solid circles.
Spectra of models are shown in solid lines, spectra of differences between models in dashed lines.
Edges between drugs and proteins represent known interactions and are shown in solid lines.
The dominant directions of the reactions are shown in solid half arrows.
The measured and predicted data are shown in solid and open circles, respectively.
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