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Past cannabis research has mainly focused on the effects of THC – which has been shown in randomized trials to induce transient psychotic experiences.
It has been shown in randomized trials to significantly improve I.Q., language and social skills in toddlers with autism, and researchers say it has even greater potential if it can be started earlier.
Lamotrigine has been shown in randomized controlled studies to be efficacious in preventing bipolar depression and rapid cycling states.
Over the past 5 years, several interventions have been shown in randomized clinical trials (RCTs) to reduce mortality in patients with ARDS.
Current interventions such as lung protective ventilation, prone ventilation, and neuromuscular blocking agents have been shown in randomized trials to improve mortality in patients with ARDS [5 7].
Lung cancer screening, like other screening tests, has the potential to save many lives, yet its benefit has not yet been shown in randomized clinical trials (RCTs).
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Finally, one should not forget that the clinical utility of the device would still need to be shown in randomized, clinical controlled trials.
The efficacy and safety of BIAsp 30 compared with other insulins were shown in randomized controlled trials [ 26- 30], and the effectiveness of BIAsp 30 in near-routine clinical practice was demonstrated by observational studies [ 31, 32].
Given that CKD is a clinical continuum and that a serum phosphorus level greater than 3.5 mg/dL is an independent predictor of all-cause mortality in dialyzed and non-dialyzed patients [ 5, 22, 23], it is also possible that controlling elevated serum phosphorus concentrations may yield beneficial results, but this remains to be shown in randomized trials.
The efficacy of triptans has been shown in several randomized, double-blind, placebo-controlled trials [3].
Chemotherapy has been shown in a randomized controlled trial to improve quality of life and extend survival in patients with inoperable cholangiocarcinoma.
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