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Prospective memory has been shown in brain imaging studies to activate the frontal lobes of the brain (as well as other areas to a lesser extent).
It may also regulate its hosts' gene expression, which has been shown in brain cancer.
Moreover, non-circulating progenitor cannot be excluded since it has been shown in brain that microglia are maintained throughout life independently of any blood input [ 45].
Moreover, as mentioned above, for several known mental retardation genes enhanced expression has been shown in brain regions, which are associated with functions impaired in mentally retarded patients.
It has been shown in brain slice preparations of C57/Bl6 mice that the depletion of the neurotransmitter dopamine leads to profound loss of dendritic spines [ 26].
Upregulation of the growth factor granulin has been shown in brain tumours (Liau et al, 2000) and in highly tumourigenic cell lines (Zhang and Serrero, 1998).
Similar(53)
Impairment of mitochondrial functioning along with increased reactive oxygen species (ROS) production have been shown in brains of PS1-KI and 3xTg-AD mice.
A reduction in ATP production was shown in brain of HD mice, including presymptomatic mice [21].
Modularity results for the most representative subject are shown in brain space, where each module is represented by a different color (Figure 8).
This was shown in brain and lymphoblasts of HD patients and in primary neurons and brain of HD transgenic mice [ 52, 201– 201].
In general, overexpression of Kca1.1 and Kca3.1 has been shown in bone, brain, breast, ovary, pancreas cancers and brain, gastrointestinal tract, melanoma and prostate cancers.
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Justyna Jupowicz-Kozak
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