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It has been shown both by experiments and simulations [15], [16] that the S4 arginines are not always embedded in lipids.
Although a crystal structure is not available for this enolase, it shares 97% homology with that of S. pneumoniae, and has been shown, both by mass spectrometry and by modeling, to be octameric [18].
This has been shown both by qualitative and quantitative analysis.
This has been shown both by mouse models and through epidemiological studies [ 9, 19].
This has been shown both by an average delay of 11-13 years from symptoms to diagnosis [ 4- 6], and through screening studies.
Rare usage of GAGs as acceptors in P. patens is in agreement with previous work which shows that functional acceptors are only very rarely GAGs - the order of preference for the nucleotide preceding the AG in functional acceptors is C > T > A > G, which has been shown both by experimental work [ 31] as well as by in silico analyses of NAGNAG splicing [ 5, 12].
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It was shown both by theoretical simulations and experimentally that the increase of amino nitrogen can be a non-monotonous function of the hydrolysis degree or proteolysis time.
This is shown both by imaging of transgenic pancreata and quantitatively using ARQiv.
Motifs are are shown both by their numerical identifiers (PFM number) and by their annotation (PFM annotation).
They are shown both by CA (Fig. 2a, variance explained by the principal axes shown in Fig. 2 b as well as by hierarchical clustering (Fig. 2 c.
This is shown both by the case of the archaebacterium Ignicoccus discussed in a later section and by the presence in mycobacteria and corynebacteria (which form a related subgroup of actinobacteria) of a unique outer lipid layer.
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