Functional electrical stimulation is a technique that has been put into practice for several years now, and has been shown to functionally restore and rehabilitate individuals with movement disorders, such as stroke, multiple sclerosis and traumatic brain injury, among others.
This may be the case since APE1 and NEIL1 have been shown to functionally interact and to stimulate the activity of hOGG1 [ 29- 32].
These NP progenitor cells express so-called stemness genes, and have been shown to functionally differentiate into the adipogenic, chondrogenic, and neurogenic lineage [ 75].
GPNMB/OA is also readily detectable in immune cells, such as macrophages and dendritic cells [5], [6], and has been shown to functionally impair T-cell activation [7], [8].
It is worth noting that the inactivation of NF-YA has been shown to functionally activate p53 and increase apoptosis in the absence of DNA damage.
The top two hub genes (FZD7 and CNIH2) are also enriched in human hippocampus (43) and CNIH2 has been shown to functionally interact with hippocampal AMPA receptor complexes, modulating receptor gating and trafficking (44, 45).
The spread of inactivation into the autosomal portion of unbalanced t(X A)s has been shown functionally (16) and by reverse transcription polymerase chain reaction expression analyses of individual genes (17).
In addition, GPCRs have also been shown to functionally regulate ion channels and help fine-tune neurotransmission.
These proteins display a high degree of sequence conservation (90% and 95% amino acid identity and similarity, respectively) and have been shown to be functionally redundant in vivo [ 20].
The co-localization of GS and MT has been shown also in functionally active astrocytes and activated HSC [7], [9], [21], [22].
