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As BRCA1 mutations have been selected against in past populations, negative selection may explain, with genetic drift and population history, the current geographic distribution of most BRCA1 allele frequencies characterized by a large number of recent and rare alleles.
Additionally, assessing whether a mutation has been selected against in past human history requires that selection be estimated in realistic demographic scenarios: human demography varies considerably between populations which can affect both the strength of selection and genetic drift.
G recognizes a new selective pressure, and that the trait that had been selected against is now being selected for; does not generalize that changing prey preference is a form of environmental change.
Recently, nucleic acid aptamers have been selected against whole living cells, with the advantage of a direct selection of ligands without prior knowledge of the target molecules, notably by using as target red blood cells [10], leukemia cells [11] small lung cancer cells [12] and rat brain tumor microvessels [13].
To make matters worse, two of the best open-side flankers have been selected against him.
To the extent that confirmation bias leads people to dismiss evidence of new or underappreciated threats the human equivalent of the cat around the corner it's a trait that should have been selected against.
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When individuals with intermediate phenotypes are favoured and extreme phenotypes are selected against, the selection is said to be stabilizing.
Larger size was selected against in several of our selection trials.
During summer, PLD-based selection reversed and individuals with shorter PLDs were selected against (Table 4, Fig. 5).
"I found out on radio that I would not be selected against France in February," Riquelme said on television.
But after the playmaker returned last summer, Makelele succumbed, and then Thuram was selected against his will and reluctantly followed them.
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