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Since the combinatorial space of these changes is immense, an overwhelming fraction of the specific combinations of changes could not have been sampled during evolution.
Clearly, an alanine residue in myosin would have been sampled during evolution since it is only one base removed from serine in the genetic code.
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All individuals that were sampled during the evolution process can be seen in Fig. 12, which displays them as red crosses on the cost space (a) and as red circles on the nodal (b) and force (c) differences spaces.
Simulations were done independently for each time period sampled during the evolution.
Gene regulatory networks have been conserved during evolution.
Thus, the Phe441 mutation could have been eliminated during evolution.
Subcellular retargeting of proteins have been rampant during evolution.
The FoxO proteins have been highly conserved during evolution.
Nevertheless, it is noteworthy the preponderance of placental samples with preferential expression of maternal alleles, indicating that, although imprinted XCI was lost during evolution, a proliferative advantage may remain for cells that inactivate the Xp in human placenta.
Residues essential for protein function are conserved during evolution.
Kinases are conserved during evolution.
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