Sentence examples for been revealed to regulate from inspiring English sources
Recently, iron metabolism has been revealed to regulate p53 signaling pathway through direct heme-p53 interaction and modulation of p53 localization, stability and function (Shen et al., 2014).
4 In addition, other p38 isoforms, p38δ and p38γ (MAPK12), have been revealed to regulate colon tumorigenesis in the same model.
Ectopic ATP synthases on the surface of hepatocytes, endothelial cells, keratinocytes, and adipocytes have been revealed to regulate cholesterol uptake, angiogenesis, extracellular ATP signaling in wound healing, and preadipocyte differentiation, respectively.
Endothelin axis has been revealed to regulate tumour growth and metastasis via various mechanisms including cell proliferation, angiogenesis, antiapoptotic activity, and immune modulation (Spinella et al, 2002; Nelson et al, 2003; Wulfing et al, 2004; Herrmann et al, 2006; Bagnato et al, 2008; Buckanovich et al, 2008).
Flavonoids were revealed to regulate insulin secretion, insulin signaling, carbohydrate digestion and glucose uptake in insulin-sensitive tissues through various intracellular signaling pathways [ 36].
In previous studies, miR171-targeted scarecrow-like proteins (SCL6/SCL22/SCL27) have been revealed to negatively regulate chlorophyll biosynthesis (Wang et al., 2010; Curaba et al., 2013).
The expression of GLUT-1 was revealed to be regulated by hypoxia in a HIF-1-dependent manner [ 17].
In the case of A. thaliana, B. cinerea infection appears to dampen the oscillating transcription of certain core clock components, leading to the suggestion that the pathogen attempts to dampen the host's defence response, because a set of genes associated with plant immune responses was revealed to be regulated by the plant's circadian clock [ 41].
Overall, 1,413 genes and many pathways were revealed to be differentially regulated.
For example, many genes known to be involved in cytoskeletal function [ 36, 37] were revealed to be differentially regulated between wild and domesticated cotton.
In vitro, Noxa was revealed to associate with a growth function regulated by glucose in human leukemia cells, and the proapoptotic proteins Bax and Bak were reported to have a role of survival rather than death in regulating T-cell proliferation, but no any related in vivo studies were performed so far.
