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Fullerene nanoparticles have been reported to specifically bind to and elicit persistent activation of hippocampal Ca2+/calmodulin-dependent protein kinase II (CaMKII), a multimeric intracellular serine/threonine kinase central to Ca2+ signal transduction and critical for synaptic plasticity, but the functional consequence of that modulation is unknown.
As expected, the currents recorded were sensitive to CFTRinh-172, which has been reported to specifically block CFTR Cl− conductance, supporting the results that the CFTR channels, not only are localized at plasma membrane, but are also functional [24].
We then examined the effect of inhibiting PI(3)K activity on the subcellular distribution of PI 3,4,5 P3 by transiently expressing a GFP fusion protein of the Grp1 PH domain (GFP-Grp1-PH), which has been reported to specifically bind PI 3,4,5 P3 [56].
Promisingly, other synthesized AAG8 ligands have been reported to specifically bind to AAG8 in the nanomolar range 11.
In addition, arsenic has been reported to specifically inhibit expression and signaling through the estrogen receptor pathway [ 13].
The latter is the enzyme that has been reported to specifically degrade PrPC but not PrPSc including sPrPSc [ 52, 53].
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Support for this model was provided by the anti-polyQ antibody 3B5H10, which was reported to specifically recognize a distinct pathologic conformation of soluble expanded polyQ.
Redskins wide receiver Peirre Garcon sustained a ligament injury of the second toe, and is reported to specifically have a plantar plate tear.
As Delta toxin was reported to specifically bind to ganglioside GM2 [7], we tested the inhibition of Delta toxin hemolytic activity with various gangliosides.
Among several sarcomeric substrates, USP25m was reported to specifically interact and rescue MyBPC1 (Myosin Binding Protein C1) from proteasome degradation, thereby raising its cellular half-life [18].
The hypothesis that CXCL10's anti-proliferative effect on endothelial cells is mediated by CXCR3 received wider acceptance after the identification of a proposed alternative splice variant in humans called CXCR3-B, which was reported to specifically mediate these effects of CXCL10 [22].
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