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A wide range of compounds that interact with Pgp1 and block drug efflux have been reported to reverse the MDR phenotype [10], [11].
This procedure has been reported to reverse the deficit in theta-burst stimulation-induced LTP in aged Sprague-Dawley [29] or Wistar rats [30].
All the techniques have been reported to reverse malignant phenotypes of tumour cells.
Calcium supplements have previously been reported to reverse vitamin B12 deficiency induced by metformin.
Furthermore, it has been reported to reverse EPD atrophy to a certain extent.
In animal studies, progestins have been reported to reverse the atheroprotective effects of E2 [ 30- 33].
Similar(34)
Antagonists of the HT2Areceptor are reported to reverse ADHD-like behaviour in some animal models.
Nevertheless, pharmacological antagonism of glucocorticoid (type II) receptor by mifepristone (RU486) was reported to reverse high fat diet-induced obesity [ 14].
In a prospective trial, calcium supplements were reported to reverse the drug interaction that causes vitamin B12 deficiency induced by metformin (19).
Cediranib (recentin, AZD2171), an oral, small-molecule, multikinase inhibitor, was reported to reverse ABCB1/P-gp/MDR1 and ABCC1/MRP1-mediated MDR by directly inhibiting their drug efflux function [67].
Pharmacological suppression of TNF- α is reported to reverse age-related defects in bone formation in a mouse fracture healing model and synergizes TGF β- and BMP-2-induced Smad signaling in differentiating osteoblasts [ 64].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com