Sentence examples for been reported to render from inspiring English sources

To determine if caspase cleavage of MEKK1 is required for apoptosis in our system, we mutated the aspartic acid residues in the caspase recognition site of rat MEKK1 to glutamate (878DTLD881 to ETLE) to create MutC; the orthologous caspase mutation of murine MEKK1 has been reported to render murine MEKK1 resistant to cleavage at this site [17], [20].

In fact, pharmacological inhibition of hENT1 in cells has been reported to render them gemcitabine resistant (Mackey et al, 1998).

Overexpression of HvPIP2 1 has been reported to render transgenic rice plants more sensitive to 100 mM NaCl (Katsuhara et al., 2003).

In preclinical models, plexin B1 suppressed proliferation, enhanced migration, stimulated Akt activation and, of particular interest, has been reported to render melanoma cell lines resistant to cisplatin-induced apoptosis [ 28].

High AKT activity has been reported to render cells more susceptible to death induced by glucose withdrawal or treating with a glycolysis inhibitor (Elstrom et al, 2004; Fan et al, 2010; Kurtoglu et al, 2007).

The yttria mole fraction is widely known to determine oxygen ion conductivity in the YSZ, and 8% mole yttria was reported to render the maximum oxygen ion conductivity [1].

In cancer cells, a panel of 4 missense mutations in the MH1 domain of Smad4 identified in human pancreatic and colorectal cancers was reported to render the mutant Smad4 a better substrate for poly-ubiquitin modification and proteasome-mediated degradation [ 20].

Overexpression and/or mutational activation of the oncogenes c-myc [ 80, 81] and ras [ 82- 84] have been reported to directly render cells resistant to TGF-β.

Interestingly, the related kinase Aurora-B has been reported to be rendered inactive by an equivalent T232E mutation in its activation loop.

The vertical transmission of HBV infection in Pakistan has been reported to be very low rendering the horizontal transmission a major risk factor for the infection acquisition.

Critical illness has been reported to involve a qualitatively diverse experience, which renders the child or adolescent unable to 'rally in the adversity' that it is exposed to.