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Furthermore, upregulation of both PD-1 and CD127 has been reported to precede disappearance of an EBV-specific CD8+ T cell from the circulation [31].
Somatisation has been shown to be associated with the development of CWP [ 18], and CWP has been reported to precede other medical conditions in primary care [ 11].
However, degeneration within discrete neuronal populations, including thalamic projection neurons and cortical interneurons, have been reported to precede general cortical atrophy and seizure phenotype in Cln1 −/− mice.
Autoimmune conditions, which occur commonly in patients with MDS (Voulgarelis et al, 2004), have also been reported to precede MDS (Dalamaga et al, 2002).
Some studies have reported polymyalgia rheumatica to occur subsequent to diagnosis of MDS (Mok et al, 1996; Espinosa et al, 2002), and polymyalgia rheumatica has been reported to precede AML (Anton, 2007).
Perhaps of more clinical importance, ACA have been reported to precede the diagnosis of SSc and have therefore been proposed as a biomarker to predict the onset of SSc [ 42, 43].
Similar(47)
Differences in circulating concentrations of antiangiogenic factors sFlt1 and soluble endoglin (sEng) and the pro-angiogenic growth factor PlGF are reported to precede the onset of preeclampsia weeks to months in low-risk pregnant women.
Rises of titres are reported to precede renal flare in anti-neutrophile cytoplasmatic antibodies (ANCA -associated vANCA -associated
For example, reduced levels of succinic acid at birth and reduced phospholipids and triglycerides in childhood, as measured within the blood metabolome, were reported to precede islet autoimmunity in children who progressed to T1D [ 88].
Depressive events are reported to precede cardiovascular events, and the manifestation of depressive episodes early in life confers a greater risk of the development of cardiovascular disease [ 4, 87].
Conflicting reports about the involvement of ROS in the rise of p H cyt suggest a complex interaction between them: in Ref. [ 32] alkalinisation of the cytosol is reported to precede ROS production, whereas Ref. [ 31] reports that p H cyt rises in response to ROS elevation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com