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Due to their anti-oxidant property, angiotensin-converting enzyme inhibitors have been reported to normalize impaired bradykinin-mediated endothelium-dependent venodilatation in smokers [ 40], and inhibition of MMP-9 by doxycycline was useful in preventing aneurysm growth [ 41, 42].
This includes several aqueous extracts of mushrooms, as for example, Ganoderma lucidum [ 9] and Ganoderma tsugae [ 10]. A. blazei extracts (1500 mg/day) have been reported to normalize the liver functions (aminotransferases) of patients with hepatitis B when given at doses of 1500 mg/day [ 11].
High dose vitamin E supplementation has been reported to normalize retinal blood flow in patients with type 1 diabetes [ 100].
Several natural occurring plants and herbal-based products with antioxidant properties have been reported to normalize glucose parameters in experimental models.
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Following beta-blocker treatment altered amplitudes and habituation of the contingent negative variation [13, 37] as well as amplitudes and latencies of pattern reversal visual evoked potentials [14] were reported to normalize.
84, 85 Severe caloric restriction for 8 weeks with a diet of refined-liquid meal-replacement formula supplemented with some vegetables (510 kcal Optifast with vegetables to a total of 600 kcal per day) was reported to normalize beta-cell function and insulin sensitivity in a small group of type II diabetics (<4 years from diagnosis).
The PMA-induced ROS production of Hv1-/ mouse granulocytes was reported to be normalized by incorporating monovalent cation channels (gramicidin peptides [32]) into their cell membrane [14].
Transcranial direct current stimulation was reported to be beneficial in normalizing the altered sleep-wake cycle in 13 children with FAS (Malakhova and Bubnov, 2011; Malakhova et al., 2011).
Cranberry is reported to interact with warfarin, increasing International Normalized ratio (INR) values by 30% [ 9], but an randomized controlled trial concluded with minor risks for significant interactions in humans [ 55].
The results obtained were normalized against FaRIB413 expression that was reported to be constitutive [ 78].
To date, no validated reference genes have been reported for normalizing gene expression in human myocardium.
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