p300 is reported to functionally collaborate with c-Jun on the MMP-1 promoter [36], and binding of p300 to the −1978/−1523 site of the MMP-1 promoter is redox-sensitive [37], which region is partially overlapped with −2067 to −1768 region around the p300-2 binding site of our study.
Several members of cytochrome P450 superfamily were reported to functionally affect lipid metabolism [ 31, 33, 85, 86].
For instance, c-Jun N-terminal kinase 1 JNK1) was reported to functionally inhibit BMP-2-induced osteogenic differentiation of C2C12 cell through phosphorylation of Runx2 at Ser104.
Although AtMYB3 and AtMYB7 have not been functionally characterized, AtMYB4 has been reported to function as a repressor of the lignin biosynthesis pathway [ 25].
Consistent with its possible function as a tumour suppressor gene, PPARγ has been reported to be functionally mutated in sporadic cases of colon cancer (Sarraf et al, 1999); nonetheless, the overall incidence of PPARγ mutations in human malignancies seems to be very rare (Ikezoe et al, 2001).
These variants exhibit diverse structural configurations and have been reported to be functionally nonequivalent.
First, the anterior and posterior insula have been reported to be functionally segregated regions with different connectivity [16 18]; however, we could not differentiate these subregions because of the constraint of the Colin27 anatomical labeling template.
Because mirror neuron activity has been reported to be functionally specific to object-oriented actions, the present study was designed to determine if the human mu rhythm also exhibits this property.
PKP2 has been reported to be functionally related to sodium channel, and decreased in PKP2 expression leaded to downregulation of sodium current in cardiomyocytes of human [ 62, 63].
