Sentence examples for been reported to downregulate from inspiring English sources

Furthermore, HIF has been reported to downregulate the intracellular adhesion molecule E-cadherin, thus contributing to loss of cell-cell adhesion in tumors [4] [6], and to induce the expression of lysyl oxidase, thereby promoting tumor cell migration and metastasis [7]).

On the other hand, microRNAs have also been reported to downregulate Slc16a1 (Pullen et al., 2011).

Accordingly, GATA-3 has been reported to downregulate STAT-4 [ 34].

Several DUBs, including A20, CYLD and USP7, have been reported to downregulate NF- κB.

Negative regulators of STAT5 include TGF-β, which has been reported to downregulate prolactin-induced JAK/STAT5 activation [ 76, 77].

MiR-125b has been reported to downregulate BAK1, thereby inducing androgen-independent growth of prostate cancer cells.

The broad-spectrum agent DZNep was reported to downregulate several HKMTs and to target EZH258.

Sprouty (SPRY) are inhibitors of receptor tyrosine kinase modulating tracheal branching in Drosophila and their alternative splicing results in multiple transcript variants (SPRY1, SPRY2, SPRY3, and SPRY4) [12,13,14], which are reported to downregulate the expression of epidermal growth factor receptor (EGFR).

On the contrary, PKA was reported to downregulate the expression of cyclin D3 and up regulate p27kip1, which block cell growth [61], [62].

Previously, pVHL was reported to downregulate metalloproteinases, such as MMP1, and upregulate MMP inhibitors (TIMPs) [48], so it is not unreasonable to suggset that genetic variants in MMP/TIMP pathways might influence tumourigenesis in VHL disease.

Furthermore, miR-152 was reported to downregulate DNA cytosine-5 -methyltransferasee 1 (DNMT1) in LNCaP, PC-3, and MDA-PCa-2b cells.