Various lncRNAs have been reported to bind to RNA binding proteins [ 5].
Recombinant AtACBP6 has been reported to bind PC in filter-binding assays [ 39].
For instances, DDX3X has been reported to bind to the cap-binding protein complex (Shih et al, 2008).
In addition to phospholipids, other ligands have been reported to bind this domain; however their binding properties remain uncharacterized.
The methyl-CpG-binding protein MeCP2 has been reported to bind to methylated CpG motifs [30] in CRE sites, which may block binding of other factors.
Apart from Ca2+-dependent carbohydrate binding, the CTLDs have been reported to bind noncarbohydrate ligands, such as proteins, lipids, CaCO3 and ice [13].
Recently, ASPP2 has been reported to bind RAS and to regulate autophagy by binding Atg5 via its N terminus.
The TSP-1 motif of ADAMTS4 has been reported to bind to its cell surface interaction partner CD3630.
PRC2 has also been reported to bind to ncRNA molecules in a size-dependent manner, predominantly around TSSs to maintain the repressed chromatin state43,44.
The S protein has a multidomain architecture and has been reported to bind to carbohydrate (sialic acid) and proteinaceous (aminopeptidase N) cell surface molecules.
Antibodies with broad neutralizing activity (nAbs) against multiple influenza virus strains or subtypes have been reported to bind the stalk of the viral hemagglutinin, suggesting that a vaccine based on this region could elicit a broadly protective immune response.
